Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease
Identifieur interne : 001575 ( Main/Exploration ); précédent : 001574; suivant : 001576Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease
Auteurs : Sid Gilman [États-Unis] ; Robert A. Koeppe [États-Unis] ; Roderick Little [États-Unis] ; Hyonggin An [États-Unis] ; Larry Junck [États-Unis] ; Bruno Giordani [États-Unis] ; Carol Persad [États-Unis] ; Mary Heumann [États-Unis] ; Kris Wernette [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2004-06.
Abstract
We used positron emission tomography (PET) with (+)‐[11C]dihydrotetrabenazine ([+]‐[11C]DTBZ) to examine striatal monoaminergic presynaptic terminal density in 20 patients with dementia with Lewy bodies (DLB), 25 with Alzheimer's disease (AD), and 19 normal elderly controls. Six DLB patients developed parkinsonism at least 1 year before dementia (DLB/PD) and 14 developed dementia before parkinsonism or at about the same time (DLB/AD). Striatal mean binding potential was decreased by 62 to 77% in the DLB/PD group and 45 to 67% in the DLB/AD compared to AD and control. Binding was lower in the DLB/PD group than the DLB/AD, but the differences reached only marginal significance in the caudate nucleus. No differences were found between AD and control groups though a few AD patients had binding values below the range of the controls. Subsequent neuropathological examination in one AD patient revealed both AD and DLB changes despite the absence of clinical parkinsonism. Both DLB groups had an anterior to posterior binding deficit gradient relative to controls, largest in posterior putamen, smaller in anterior putamen, smallest in caudate nucleus. The DLB/AD group showed significant binding asymmetry only in posterior putamen. We conclude that PET with (+)‐[11C]DTBZ differentiates DLB from AD, and decreased binding in AD may indicate subclinical DLB pathology in addition to AD pathology. Ann Neurol 2004
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DOI: 10.1002/ana.20088
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Koeppe</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Radiology, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Little, Roderick" sort="Little, Roderick" uniqKey="Little R" first="Roderick" last="Little">Roderick Little</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Biostatistics, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="An, Hyonggin" sort="An, Hyonggin" uniqKey="An H" first="Hyonggin" last="An">Hyonggin An</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Biostatistics, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Junck, Larry" sort="Junck, Larry" uniqKey="Junck L" first="Larry" last="Junck">Larry Junck</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Giordani, Bruno" sort="Giordani, Bruno" uniqKey="Giordani B" first="Bruno" last="Giordani">Bruno Giordani</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Psychiatry, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Psychiatry, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Heumann, Mary" sort="Heumann, Mary" uniqKey="Heumann M" first="Mary" last="Heumann">Mary Heumann</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Wernette, Kris" sort="Wernette, Kris" uniqKey="Wernette K" first="Kris" last="Wernette">Kris Wernette</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Neurology, Division of Nuclear Medicine, University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-06">2004-06</date><biblScope unit="volume">55</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="774">774</biblScope><biblScope unit="page" to="780">780</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">8855CA3B11BB197AB956C7D59CFFEBD30D56D742</idno><idno type="DOI">10.1002/ana.20088</idno><idno type="ArticleID">ANA20088</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We used positron emission tomography (PET) with (+)‐[11C]dihydrotetrabenazine ([+]‐[11C]DTBZ) to examine striatal monoaminergic presynaptic terminal density in 20 patients with dementia with Lewy bodies (DLB), 25 with Alzheimer's disease (AD), and 19 normal elderly controls. Six DLB patients developed parkinsonism at least 1 year before dementia (DLB/PD) and 14 developed dementia before parkinsonism or at about the same time (DLB/AD). Striatal mean binding potential was decreased by 62 to 77% in the DLB/PD group and 45 to 67% in the DLB/AD compared to AD and control. Binding was lower in the DLB/PD group than the DLB/AD, but the differences reached only marginal significance in the caudate nucleus. No differences were found between AD and control groups though a few AD patients had binding values below the range of the controls. Subsequent neuropathological examination in one AD patient revealed both AD and DLB changes despite the absence of clinical parkinsonism. Both DLB groups had an anterior to posterior binding deficit gradient relative to controls, largest in posterior putamen, smaller in anterior putamen, smallest in caudate nucleus. The DLB/AD group showed significant binding asymmetry only in posterior putamen. We conclude that PET with (+)‐[11C]DTBZ differentiates DLB from AD, and decreased binding in AD may indicate subclinical DLB pathology in addition to AD pathology. Ann Neurol 2004</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name></region><name sortKey="An, Hyonggin" sort="An, Hyonggin" uniqKey="An H" first="Hyonggin" last="An">Hyonggin An</name><name sortKey="Giordani, Bruno" sort="Giordani, Bruno" uniqKey="Giordani B" first="Bruno" last="Giordani">Bruno Giordani</name><name sortKey="Heumann, Mary" sort="Heumann, Mary" uniqKey="Heumann M" first="Mary" last="Heumann">Mary Heumann</name><name sortKey="Junck, Larry" sort="Junck, Larry" uniqKey="Junck L" first="Larry" last="Junck">Larry Junck</name><name sortKey="Koeppe, Robert A" sort="Koeppe, Robert A" uniqKey="Koeppe R" first="Robert A." last="Koeppe">Robert A. Koeppe</name><name sortKey="Little, Roderick" sort="Little, Roderick" uniqKey="Little R" first="Roderick" last="Little">Roderick Little</name><name sortKey="Persad, Carol" sort="Persad, Carol" uniqKey="Persad C" first="Carol" last="Persad">Carol Persad</name><name sortKey="Wernette, Kris" sort="Wernette, Kris" uniqKey="Wernette K" first="Kris" last="Wernette">Kris Wernette</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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